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NEUROVASCULAR MECHANISMS OF BRAIN FUNCTION AND DISEASE

Published on AidPage by IDILOGIC on Jun 24, 2005
Administered by:

Department of Health and Human Services, National Institutes of Health, National Institutes of Health
(see all US Federal Agencies)

Explore all postings for this grant program:
  • Original Grant - Mar 8, 2004
Applications Due:


Multiple Receipt Dates - See Link to Full Announcement for details.

total funding: Not Available
max award: none
min award: none
cost sharing, matching: No
number of awards: Not Available
type of funding: Grant
Description:

The goal of this Program Announcement with set-aside funds (PAS) is to
invite applications for studying the integration of neurobiological and
cerebrovascular mechanisms in the adult, aged and pediatric brain in
health and disease. This PAS encourages studies focused on improving our
understanding of the dynamic interactions within the neurovascular unit
(NVU), a construct consisting of brain microvascular endothelium, glia,
neurons and the extracellular matrix that maintains spatial relations
among them. Knowledge of these interactions has the potential to
stimulate new strategies for basic, translational and clinical research in
many neurological disorders, including stroke, vascular dementia, and
intracerebral hemorrhage. Among the challenges to be addressed are:
generate new hypotheses and conduct exploratory work on microvesselneuron
communication; increase our knowledge about cell-cell signaling and how
insults to the endothelium affect parenchymal cell damage, which applies
not only to stroke, but may also contribute to understanding neurological
disorders in which vascular changes are observed; and, elucidate
mechanisms by which neurons communicate with blood vessels through
interactions with non-neuronal cells in the microenvironment including
endothelium, pericytes, astrocytes, oligodendrocytes and microglia.

Who can apply:

Anyone/General Public
City Or Township Governments
County Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Individual/Family
Minority Group
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Profit Organization
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)

Eligible functional categories:
Funding Sources:

Extramural Research Programs in the Neurosciences and Neurological Disorders

More Information:

http://grants.nih.gov/grants/guide/pa-files/PAS-04-072.html

If you have problems accessing the full announcement, please contact: NIH OER Webmaster

Address Info:

Office of Extramural Programs
6705 Rockledge Drive
Bethesda, MD 20892-7963

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